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PHM-27 (human)

PHM-27 (human) belongs to the peptide family derived from VIP/PHM precursors, containing residues suited for receptor-binding exploration. Conformational adaptability enables structural modeling of neuroendocrine regulatory pathways. Sequence motifs affect solubility and folding patterns. Research applies it to biosynthesis mapping and peptide-ligand interaction studies.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
PHM-27 (human)(CAS 87403-73-4)

CAT No: V1314

CAS No:87403-73-4

Synonyms/Alias:PHM-27 (human);87403-73-4;118025-43-7;Heptacosapeptide, Porcine Intestinal;PHM-27 human;Peptide Histidine Methionine;AKOS024456933;DA-66674;PD079251;L-Methioninamide,l-histidyl-L-alanyl-L-a-aspartylglycyl-L-valyl-L-phenylalanyl-L-threonyl-L-seryl-L-a-aspartyl-L-phenylalanyl-L-seryl-L-Lysyl-L-Leucyl-L-Leucylglycyl-L-glutaminyl-l-leucyl-l-seryl-l-al;

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cGMP Peptide
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  • Drug master files (DMF) filing
M.F/Formula
C135H214N34O40S
M.W/Mr.
2985.4
Sequence
One Letter Code:HADGVFTSDFSKLLGQLSAKKYLESLM
Three Letter Code:H-His-Ala-Asp-Gly-Val-Phe-Thr-Ser-Asp-Phe-Ser-Lys-Leu-Leu-Gly-Gln-Leu-Ser-Ala-Lys-Lys-Tyr-Leu-Glu-Ser-Leu-Met-NH2
Biological Activity
Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.
Long-term Storage Conditions
Soluble to 1 mg/ml in 5% acetonitrile / water
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C135H214N34O40S/c1-68(2)49-89(155-124(198)92(52-71(7)8)156-118(192)86(35-25-28-47-138)152-131(205)100(64-171)166-127(201)94(54-77-29-19-17-20-30-77)161-128(202)98(59-108(183)184)162-133(207)102(66-173)167-135(209)110(76(15)174)169-129(203)96(55-78-31-21-18-22-32-78)163-134(208)109(73(11)12)168-105(178)62-144-116(190)97(58-107(181)182)154-113(187)74(13)146-114(188)82(139)57-80-60-142-67-145-80)115(189)143-61-104(177)148-87(40-42-103(140)176)120(194)157-93(53-72(9)10)125(199)165-99(63-170)130(204)147-75(14)112(186)150-84(33-23-26-45-136)117(191)151-85(34-24-27-46-137)119(193)160-95(56-79-36-38-81(175)39-37-79)126(200)158-91(51-70(5)6)123(197)153-88(41-43-106(179)180)121(195)164-101(65-172)132(206)159-90(50-69(3)4)122(196)149-83(111(141)185)44-48-210-16/h17-22,29-32,36-39,60,67-76,82-102,109-110,170-175H,23-28,33-35,40-59,61-66,136-139H2,1-16H3,(H2,140,176)(H2,141,185)(H,142,145)(H,143,189)(H,144,190)(H,146,188)(H,147,204)(H,148,177)(H,149,196)(H,150,186)(H,151,191)(H,152,205)(H,153,197)(H,154,187)(H,155,198)(H,156,192)(H,157,194)(H,158,200)(H,159,206)(H,160,193)(H,161,202)(H,162,207)(H,163,208)(H,164,195)(H,165,199)(H,166,201)(H,167,209)(H,168,178)(H,169,203)(H,179,180)(H,181,182)(H,183,184)/t74-,75-,76+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,109-,110-/m0/s1
InChI Key
YLBIOQUUAYXLJJ-WZUUGAJWSA-N

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