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(Sar1,Ala8)-Angiotensin II

(Sar1,Ala8)-Angiotensin II features a sarcosine substitution at position 1 and an alanine at position 8, which refine receptor-binding characteristics and modulate peptide stability. These alterations influence the peptide's bioactivity and its interaction with the angiotensin II receptor. Researchers use this analog to investigate the structure-activity relationships of angiotensin peptides and their cardiovascular effects.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
(Sar1,Ala8)-Angiotensin II(CAS 38027-95-1)

CAT No: A15074

CAS No:38027-95-1

Synonyms/Alias:38027-95-1;Siaa II;Angiotensin II, 1-sar-5-ile-8-ala-;1-Sar-5-ile-8-ala-angiotensin II;1-Sarcosyl-5-isoleucyl-8-alanine angiotensin II;Angiotensin II, 1-sarcosyl-5-isoleucyl-8-alanine-;CHEMBL312754;(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid;DTXSID90191436;Sar-Arg-Val-Tyr-Ile-His-Pro-Ala;Angiotensin II, 1-(N-methylglycine)-5-L-isoleucine-8-L-alanine-;(Sar 1,Ala8)-Angiotensin II;SCHEMBL11024001;DTXCID00113927;BDBM50228894;FS108518;(Ile?)-Saralasin;Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OH;(2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-5-CARBAMIMIDAMIDO-2-[2-(METHYLAMINO)ACETAMIDO]PENTANAMIDO]-3-METHYLBUTANAMIDO]-3-(4-HYDROXYPHENYL)PROPANAMIDO]-3-METHYLPENTANAMIDO]-3-(1H-IMIDAZOL-4-YL)PROPANOYL]PYRROLIDIN-2-YL]FORMAMIDO}PROPANOIC ACID;

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M.F/Formula
C43H67N13O10
M.W/Mr.
926.1
Sequence
One Letter Code:GRVYIHPA
Three Letter Code:H-Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OH
InChI
InChI=1S/C43H67N13O10/c1-7-24(4)35(40(63)53-31(19-27-20-47-22-49-27)41(64)56-17-9-11-32(56)38(61)50-25(5)42(65)66)55-37(60)30(18-26-12-14-28(57)15-13-26)52-39(62)34(23(2)3)54-36(59)29(51-33(58)21-46-6)10-8-16-48-43(44)45/h12-15,20,22-25,29-32,34-35,46,57H,7-11,16-19,21H2,1-6H3,(H,47,49)(H,50,61)(H,51,58)(H,52,62)(H,53,63)(H,54,59)(H,55,60)(H,65,66)(H4,44,45,48)/t24-,25-,29-,30-,31-,32-,34-,35-/m0/s1
InChI Key
XIEWFECSPPTVQN-YXRHCLBHSA-N

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