Selepressin

Selepressin (INN), also known as [Phe(2),Ile(3), Hgn(4),Orn(iPr)(8)]vasopressin) is a potent, highly selective, short-acting peptide full agonist of the vasopressin 1A receptor and analog of vasopressin which is under development by Ferring Pharmaceuticals for the treatment of vasodilatory hypotension in septic shock.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Selepressin(CAS 876296-47-8)

CAT No: 10-101-173

CAS No:876296-47-8

Synonyms/Alias:SELEPRESSIN;Fe202158;876296-47-8;Fe 202158;Selepressin [USAN:INN];Selepressin [INN];UNII-8P2T76M0SJ;selepresina;selepressine;8P2T76M0SJ;FE-202158;(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-10-(4-amino-4-oxobutyl)-7-(2-amino-2-oxoethyl)-16-benzyl-13-[(2S)-butan-2-yl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-5-(propan-2-ylamino)pentan-2-yl]pyrrolidine-2-carboxamide;SELEPRESSIN [USAN];SELEPRESSIN [WHO-DD];Glycinamide, L-cysteinyl-L-phenylalanyl-L-isoleucyl-6-oxo-L-lysyl-L-asparaginyl-L-cysteinyl-L-prolyl-n5-(1-methylethyl)-L-ornithyl-, cyclic (1-6)-disulfide;CHEMBL1817709;DTXSID90236538;(2-L-PHENYLALANINE,3-L-ISOLEUCINE,4-(6-OXO-L-LYSINE), 8-(5-N-(PROPAN-2-YL)-L-ORNITHINE))HUMAN VASOPRESSIN;selepressinum;(2S)-1-((4R,7S,10S,13S,16S,19R)-19-amino-10-(4-amino-4-oxobutyl)-7-(2-amino-2-oxoethyl)-16-benzyl-13-((2S)-butan-2-yl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl)-N-((2S)-1-((2-amino-2-oxoethyl)amino)-1-oxo-5-(propan-2-ylamino)pentan-2-yl)pyrrolidine-2-carboxamide;SCHEMBL19712230;GTPL11454;DTXCID20159029;BDBM50350870;DB12495;HY-105239;CS-0025461;Q21098876;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C46H73N13O11S2
M.W/Mr.
1048.3
Sequence
One Letter Code:CFIXNCPXG
Three Letter Code:H-Cys(1)-Phe-Ile-hGln-Asn-Cys(1)-Pro-Orn(iPr)(iPr)-Gly-NH2
Labeling Target
Arginine Vasopressin Receptor 1A
Application
Selepressin is deveolped for the treatment of vasodilatory hypotension in septic shock.
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Activity
Agonist
Biological Activity
Selepressin, also known as FE-202158, is a potent, selective vasopressin V1a receptor agonist potentially for the treatment of septic shock.
Areas of Interest
Septic shock
Functions
Type 1 angiotensin receptor binding
Target
Vasopressin Receptor
Source#
Synthetic
Long-term Storage Conditions
Soluble in DMSO.
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions
Dry, dark and at 0 - 4 °C
Solubility
-20 °C
Organism
Human
InChI
InChI=1S/C46H73N13O11S2/c1-5-26(4)38-45(69)54-30(14-9-17-35(48)60)41(65)56-32(21-36(49)61)42(66)57-33(24-72-71-23-28(47)39(63)55-31(43(67)58-38)20-27-12-7-6-8-13-27)46(70)59-19-11-16-34(59)44(68)53-29(15-10-18-51-25(2)3)40(64)52-22-37(50)62/h6-8,12-13,25-26,28-34,38,51H,5,9-11,14-24,47H2,1-4H3,(H2,48,60)(H2,49,61)(H2,50,62)(H,52,64)(H,53,68)(H,54,69)(H,55,63)(H,56,65)(H,57,66)(H,58,67)/t26-,28-,29-,30-,31-,32-,33-,34-,38-/m0/s1
InChI Key
JCVQBJTWWDYUFQ-MRUTUVJXSA-N
ShelfLife
>2 years if stored properly

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