Tertiapin LQ

Tertiapin LQ is a modified bee venom peptide with characteristic disulfide bonds that stabilize its compact scaffold. Residue substitutions modulate binding affinity toward selected ion channels. Researchers study its structure through NMR and electrophysiology to map channel-interaction determinants. Applications include toxin engineering, channel-selectivity research, and disulfide-rich scaffold exploration.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R2772

Synonyms/Alias:Tertiapin LQ; HB1107; AKOS024458102

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cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C106H179N33O24S4
M.W/Mr.
2428
Sequence
One Letter Code:ALCNCNRIIIPLQCWKKCGKK
Three Letter Code: H-Ala-Leu-Cys(1)-Asn-Cys(2)-Asn-Arg-Ile-Ile-Ile-Pro-Leu-Gln-Cys(1)-Trp-Lys-Lys-Cys(2)-Gly-Lys-Lys-NH2
InChI
InChI=1S/C106H179N33O24S4/c1-12-56(8)83-103(161)137-84(57(9)13-2)104(162)138-85(58(10)14-3)105(163)139-42-26-34-78(139)102(160)131-70(44-55(6)7)94(152)126-68(35-36-79(112)140)92(150)133-75-51-166-167-52-76(134-95(153)69(43-54(4)5)127-87(145)59(11)111)100(158)130-73(47-81(114)142)98(156)135-77(101(159)129-72(46-80(113)141)97(155)125-67(93(151)136-83)33-25-41-118-106(116)117)53-165-164-50-74(88(146)120-49-82(143)121-64(30-18-22-38-108)89(147)122-63(86(115)144)29-17-21-37-107)132-91(149)66(32-20-24-40-110)123-90(148)65(31-19-23-39-109)124-96(154)71(128-99(75)157)45-60-48-119-62-28-16-15-27-61(60)62/h15-16,27-28,48,54-59,63-78,83-85,119H,12-14,17-26,29-47,49-53,107-111H2,1-11H3,(H2,112,140)(H2,113,141)(H2,114,142)(H2,115,144)(H,120,146)(H,121,143)(H,122,147)(H,123,148)(H,124,154)(H,125,155)(H,126,152)(H,127,145)(H,128,157)(H,129,159)(H,130,158)(H,131,160)(H,132,149)(H,133,150)(H,134,153)(H,135,156)(H,136,151)(H,137,161)(H,138,162)(H4,116,117,118)/t56-,57-,58-,59-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,83-,84-,85-/m0/s1
InChI Key
WUMIWMIQOSXVPZ-ZPWFPUPGSA-N

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