TFA-Gly-OH contains a glycine residue bearing a carboxylic acid (-COOH) and a free amino functionality (-NH2) as indicated by the "Gly-OH" portion, with the amino group converted to a trifluoroacetyl (TFA) amide. The molecule therefore presents a trifluoroacetamide carbonyl (-NHCOCF3) as a protecting modification that reduces the nucleophilicity of the amino group while retaining the carboxylic acid for subsequent coupling chemistry. TFA-Gly-OH is commonly used as an amino acid derivative and peptide-building block in stepwise peptide synthesis and as a chemically defined glycine precursor for preparing more complex glycine-containing intermediates and conjugates.
CAT No: CP25819
CAS No:383-70-0
Synonyms/Alias:383-70-0;N-(Trifluoroacetyl)glycine;2-(2,2,2-Trifluoroacetamido)aceticacid;N-(Trifluoroacetyl)aminoaceticacid;[(Trifluoroacetyl)amino]aceticacid;N-Trifluoroacetylglycine;TFA-GLY-OH;TRIFLUOROACETYLGLYCINE;IFAXXCBMQJNCCF-UHFFFAOYSA-N;(TRIFLUOROACETAMIDO)ACETICACID;2-(TRIFLUOROACETAMIDO)ACETICACID;(2,2,2-Trifluoro-acetylamino)-aceticacid;2-[(2,2,2-trifluoroacetyl)amino]aceticacid;AC1Q75XJ;N-(Trifluoroacetyl)-Gly-OH;C4H4F3NO3;SCHEMBL1460181;CTK4H9846;MolPort-003-850-692;AC1L3819;N-(2,2,2-Trifluoroacetyl)glycine;ZINC1568170;N-ALPHA-TRIFLUOROACETYLGLYCINE;NSC306126;N-ALPHA-TRIFLUORACETYL-GLYCINE
Chemical Name:N-alpha-Trifluoracetyl-glycin
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