Z-DEVD-AFC
AFC (7-amino-4-trifluoromethylcoumarin)-derived caspase substrates are widely used for the fluorimetric detection of various caspase activities. Cleavage of AFC peptides by caspases generate strongly fluorescent AFC that is monitored fluorimetrically at 500-510 nm with excitation of 370-390 nm.
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| CAT# | A55006 |
| M.W/Mr. | 821.7 |
| Sequence | One Letter Code: Z-DEVD-AFC
Three Letter Code: Z-Asp-Glu-Val-Asp-AFC |
| Storage | -20°C desiccated and protected from light |
References | 1.Gurtu V, et al. (1997). Fluorometric and colorimetric detection of caspase activity associated with apoptosis. Anal Biochem 251, 98-102;
2. Martins LM, et al. (1997). Activation of multiple interleukin-1beta converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis. J Biol Chem 272, 7421-30;
3. Deveraux QL, et al. (1997). X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388, 300-4;
4. Xiang J, et al. (1996). BAX-induced cell death may not require interleukin 1 ?-converting enzyme-like proteases.
5. Proc Natl Acad Sci USA 93, 14559-63. |
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