Z-glycine N-carboxyanhydride is a glycine-derived amino acid carboxyanhydride (NCA) in which the amino component is protected as the Z (benzyloxycarbonyl, Cbz) carbamate. The NCA ring contains an activated carbonyl that can undergo aminolysis to generate a growing peptide chain, while the Z group provides protection for the newly formed amino terminus and the molecule retains the glycine side chain (a hydrogen substituent) characteristic of glycine. Z-glycine N-carboxyanhydride is used as a reagent for controlled peptide synthesis in solution-phase or polymerization-like NCA methodologies, and its defined activated structure makes it suitable for preparing peptide-related intermediates and labeled or modified glycine-containing sequences under conditions that promote ring-opening polymerization.
CAT No: CP00915
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