Z-L-glutamic acid γ-tert.butyl ester N- carboxyanhydride is a protected, activated glutamate-derived amino acid N-carboxyanhydride (NCA) in which the α-amino group is incorporated into the NCA ring and the side-chain γ-carboxyl functionality is masked as a tert-butyl ester while the α-carboxyl is present as part of the NCA framework. The molecule contains the NCA-activated carbonyl system that can undergo ring-opening polymerization chemistry, along with a Z (benzyloxycarbonyl) protecting group that controls chemoselectivity at the amino functionality and a tert-butyl ester that stabilizes the γ-carboxyl during peptide-chain growth. As an NCA building block, it is used in peptide synthesis contexts to generate glutamate-containing polypeptide segments under conditions that promote NCA ring opening, while the Z and tert-butyl ester groups provide orthogonal protection patterns for subsequent deprotection and downstream derivatization.
CAT No: CP00750
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