Z-Phe-chloromethylketone is a protected phenylalanine-derived amino acid derivative in which the amino group is masked as a Z (benzyloxycarbonyl, Cbz) carbamate while the side chain bears a chloromethyl ketone functionality. The molecule contains a carboxyl group and a chloromethyl ketone moiety (-CH2-Cl attached to a ketone), providing an electrophilic handle alongside the protected amino functionality, and the stereochemistry is not specified in the product name. In synthetic and chemical biology workflows, it is used as a phenylalanine-based electrophilic building block for preparing peptide-related intermediates and for labeling or inhibitor-analogue studies that rely on reaction of the chloromethyl ketone with nucleophiles under controlled conditions.
CAT No: CP26904
CAS No:26049-94-5
Synonyms/Alias:ZPCK;Z-L-Phechloromethylketone;26049-94-5;CHEMBL303579;OYHLRJGDELITAF-INIZCTEOSA-N;NSC251810;L-Carbobenzyloxyphenylalanylchloromethylketone;N-Carbobenzoxy-L-phenylalanyl-chloromethylketone;N-Carbobenzyloxy-L-phenylalanylchloromethylketone;Benzyl((1S)-3-chloro-2-oxo-1-benzylpropyl)carbamate;1-BENZYLOXYCARBONYLAMINOPHENETHYLCHLOROMETHYLKETONE;Carbamicacid,((1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl)-,phenylmethylester;Carbamicacid,[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-,phenylmethylester;Carbamicacid,N-((1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl)-,phenylmethylester;Carbamicacid,N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-,phenylmethylester;Z-Phe-CMK;PubChem11552;N(.alpha.)-Benzyloxycarbonylphenylalanylchloromethane;Spectrum2_001493;Spectrum3_001809;Lopac-C-9511;N-(Benzyloxycarbonyl)-L-phenylalaninechloromethylketone;N-((Benzyloxy)carbonyl)-L-phenylalaninechloromethylketone;Lopac0_000290;BSPBio_003397
2. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
3. High fat diet and GLP-1 drugs induce pancreatic injury in mice
4. The spatiotemporal control of signalling and trafficking of the GLP-1R
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