Cyclo(-Arg-Gly-Asp-D-Phe-Lys)

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT#R04029
Chemical Structure
Explanationcyclo[-Arg-Gly-Asp-D-Phe-Lys-]
Synonyms/Aliasc(RGDfK)
M.F/FormulaC27H42N9O7
M.W/Mr.603.68
SequenceOne Letter Code:Cyclo(-RGDfK)
Three Letter Code: Cyclo(Arg-Gly-Asp-Phe-Lys)
Biological ActivityCyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface.
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