Cyclo(-Arg-Gly-Asp-D-Phe-Lys)

cyclo[-Arg-Gly-Asp-D-Phe-Lys-]

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CAT#R04029
Chemical Structure
CAS161552-03-0
Synonyms/Aliasc(RGDfK)
M.F/FormulaC27H42N9O7
M.W/Mr.603.68
SequenceOne Letter Code:Cyclo(-RGDfK)
Three Letter Code: Cyclo(Arg-Gly-Asp-Phe-Lys)
Biological ActivityCyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface.
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