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Cyclo(-Arg-Gly-Asp-D-Phe-Lys)

cyclo[-Arg-Gly-Asp-D-Phe-Lys-]

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Cyclo(-Arg-Gly-Asp-D-Phe-Lys)(CAS 161552-03-0)

CAT No: R04029

CAS No:161552-03-0

Synonyms/Alias:Cyclo(-RGDfK);161552-03-0;Cyclo (-RGDfK);2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;CHEMBL2332367;cyclo-(Arg-Gly-Asp-D-Phe-Lys);cyclo(Arg-Gly-Asp-DPhe-Lys);cyclo(Arg-Gly-Asp-D-Phe-Lys);cyclo-[Arg-Gly-Asp-d-Phe-Lys];2-((2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid;Cyclo(RGDfK);cyclo[Arg-Gly-Asp-d-Phe-Lys];cyclo-rgdfk;Cyclo(-Arg-Gly-Asp-D-Phe-Lys);cyclo(-RGDfK)?;SCHEMBL7743533;SCHEMBL17364341;DTXSID30436575;NVHPXYIRNJFKTE-HAGHYFMRSA-N;EX-A4060;HY-P0023;BDBM50429459;AKOS030526608;CS-4203;DA-72462;FC110054;MS-30644;Cyclo(-Arg-Gly-Asp-D-Phe-Lys) Trifluoroacetate;Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate salt;

Custom Peptide Synthesis
cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C27H41N9O7
M.W/Mr.
603.7
Sequence
Three Letter Code:cyclo[Arg-Gly-Asp-D-Phe-Lys]
Biological Activity
Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface.
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C27H41N9O7/c28-11-5-4-9-18-24(41)34-17(10-6-12-31-27(29)30)23(40)32-15-21(37)33-20(14-22(38)39)26(43)36-19(25(42)35-18)13-16-7-2-1-3-8-16/h1-3,7-8,17-20H,4-6,9-15,28H2,(H,32,40)(H,33,37)(H,34,41)(H,35,42)(H,36,43)(H,38,39)(H4,29,30,31)/t17-,18-,19+,20-/m0/s1
InChI Key
NVHPXYIRNJFKTE-HAGHYFMRSA-N

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