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  5. ((Cys31,Nva34)-Neuropeptide Y (27-36))2

((Cys31,Nva34)-Neuropeptide Y (27-36))2

((Cys31,Nva34)-Neuropeptide Y (27-36))2 is a covalently linked dimeric NPY fragment engineered with cysteine and norvaline substitutions. The dimeric architecture enhances avidity and allows exploration of multivalent receptor engagement. Its sequence focuses on the C-terminal recognition region critical for Y-receptor binding. Researchers apply it to probe oligomeric effects on neuropeptide signaling and receptor clustering.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
((Cys31,Nva34)-Neuropeptide Y (27-36))2(CAS 172997-92-1)

CAT No: N05030

CAS No:172997-92-1

Synonyms/Alias:172997-92-1;((Cys31,Nva34)-Neuropeptide Y (27-36))2;BWX 46;EX-A9089;HY-P1325;BDBM50049745;AKOS024456920;FC109067;PD079242;CS-0029408;((Cys31, Nva 34)-Neuropeptide Y (27-36))2;(H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2;

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M.F/Formula
C116H186N36O28S2
M.W/Mr.
2597.1
Sequence
Three Letter Code:H-Tyr-Ile-Asn-Leu-Cys(1)-Thr-Arg-Nva-Arg-Tyr-NH2.H-Tyr-Ile-Asn-Leu-Cys(1)-Thr-Arg-Nva-Arg-Tyr-NH2
Biological Activity
Potent and highly selective NPY Y5 receptor agonist (Ki values are 0.85, 42, 3015 and 245 nM at Y5, Y1, Y2 and Y4 receptors respectively). Stimulates food intake gradually following intrahypothalamic administration in rats.
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C116H186N36O28S2/c1-13-21-73(97(165)137-75(23-17-43-131-113(123)124)101(169)141-79(93(121)161)51-65-31-39-69(157)40-32-65)135-99(167)77(25-19-45-133-115(127)128)139-111(179)91(61(11)153)151-107(175)85(147-103(171)81(47-57(5)6)143-105(173)83(53-87(119)159)145-109(177)89(59(9)15-3)149-95(163)71(117)49-63-27-35-67(155)36-28-63)55-181-182-56-86(148-104(172)82(48-58(7)8)144-106(174)84(54-88(120)160)146-110(178)90(60(10)16-4)150-96(164)72(118)50-64-29-37-68(156)38-30-64)108(176)152-92(62(12)154)112(180)140-78(26-20-46-134-116(129)130)100(168)136-74(22-14-2)98(166)138-76(24-18-44-132-114(125)126)102(170)142-80(94(122)162)52-66-33-41-70(158)42-34-66/h27-42,57-62,71-86,89-92,153-158H,13-26,43-56,117-118H2,1-12H3,(H2,119,159)(H2,120,160)(H2,121,161)(H2,122,162)(H,135,167)(H,136,168)(H,137,165)(H,138,166)(H,139,179)(H,140,180)(H,141,169)(H,142,170)(H,143,173)(H,144,174)(H,145,177)(H,146,178)(H,147,171)(H,148,172)(H,149,163)(H,150,164)(H,151,175)(H,152,176)(H4,123,124,131)(H4,125,126,132)(H4,127,128,133)(H4,129,130,134)/t59-,60-,61+,62+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,89-,90-,91-,92-/m0/s1
InChI Key
NCCWKDKNIQUYAI-JULUKTQUSA-N

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