EA-230, a powerful and precise inhibitor, finds its application in the biomedical realm for efficacious intervention against a myriad of cancer types, encompassing lung, breast, and colorectal cancer. Employing a mechanism targeting distinct protein kinases implicated in the proliferation of tumors and the formation of blood vessels, this compound exhibits remarkable potential.
CAT No: R2054
CAS No:503844-09-5
Chemical Name:(2S)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-aminopropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-methylbutanoic acid
EA-230 is a synthetic tetrapeptide with notable immunomodulatory properties, originally derived from a fragment of the beta-human chorionic gonadotropin (β-hCG) hormone. As a peptide compound, it is structurally characterized by its short amino acid sequence and has garnered significant attention in biochemical research due to its capacity to influence immune system pathways and cellular signaling. Its unique sequence and functional profile make it a valuable tool for investigating peptide-mediated regulation of inflammation, immune cell activity, and related biochemical mechanisms in preclinical and laboratory settings.
Immunology research: EA-230 is widely employed in immunological studies to elucidate the mechanisms underlying immune modulation and cytokine regulation. Researchers utilize this tetrapeptide to probe the effects of exogenous peptides on innate and adaptive immune responses, focusing on its ability to modulate the activity of immune cells such as macrophages, dendritic cells, and lymphocytes. By incorporating EA-230 into in vitro and ex vivo models, investigators can dissect signaling cascades and gene expression changes associated with immune activation, tolerance, or suppression, thereby enhancing the understanding of peptide-driven immunological processes.
Inflammation pathway analysis: The compound serves as a valuable reagent for dissecting the molecular pathways involved in inflammation. Its structural similarity to endogenous regulatory peptides enables researchers to study the modulation of pro-inflammatory and anti-inflammatory mediators, including the expression of cytokines, chemokines, and adhesion molecules. By integrating EA-230 into cell-based assays or tissue explant models, scientists can systematically evaluate the peptide's impact on key inflammatory markers, shedding light on the biochemical basis of inflammation resolution and immune homeostasis.
Peptide-receptor interaction studies: Owing to its defined sequence, EA-230 is frequently used in receptor binding and signaling assays aimed at characterizing peptide-receptor interactions. Researchers employ it to identify potential cellular targets, quantify binding affinities, and map downstream signaling events. These studies are instrumental in elucidating how synthetic peptides can mimic or modulate endogenous signaling, providing insights into receptor specificity, ligand-receptor dynamics, and the broader implications of peptide therapeutics in experimental systems.
Peptide stability and pharmacokinetics research: The compound is also utilized in studies focused on peptide stability, degradation, and bioavailability. By tracking its metabolic fate in various biological matrices, researchers can assess the influence of sequence modifications on proteolytic resistance and half-life. Such investigations are crucial for optimizing peptide design, improving delivery strategies, and understanding the physicochemical factors that govern peptide persistence and activity in experimental models.
Analytical method development: EA-230 functions as a standard or reference material in the development and validation of analytical techniques for peptide quantification and characterization. Its well-defined structure and physicochemical properties make it suitable for calibrating mass spectrometry, high-performance liquid chromatography (HPLC), and related analytical platforms. These applications support the advancement of robust, reproducible methodologies for peptide analysis, facilitating high-precision detection and quantification in complex biological samples or formulated products.
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