Elpamotide is a promising immunotherapy product utilized in the biomedical industry. This innovative drug stimulates the patient's immune system, aiding in the recognition and destruction of cancer cells.
CAT No: R2041
CAS No:673478-49-4
Chemical Name:(2S,3S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-4-oxobutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoic acid
Elpamotide is a synthetic peptide compound designed as an epitope-specific sequence derived from vascular endothelial growth factor receptor 2 (VEGFR2). As a member of the peptide class, it is recognized for its ability to mimic antigenic determinants and is frequently used in research exploring the modulation of immune responses. Its sequence specificity and stability make it a valuable tool for investigating peptide-mediated cellular mechanisms, particularly in the context of angiogenesis and immune recognition. Owing to its well-defined structure and bioactivity, Elpamotide serves as a key reagent in studies aiming to elucidate peptide-protein interactions and the functional consequences of targeted immune engagement.
Epitope Mapping: In immunological research, Elpamotide is widely utilized for the mapping of T-cell epitopes. Its defined amino acid sequence enables precise identification of peptide regions that interact with major histocompatibility complex (MHC) molecules and T-cell receptors. This application is critical for dissecting the molecular basis of antigen recognition, facilitating the design of immunogenic peptides, and advancing understanding of adaptive immune specificity. Researchers employ Elpamotide in in vitro assays to evaluate T-cell activation, proliferation, and cytokine release in response to epitope presentation.
Peptide-Based Vaccine Research: Elpamotide is frequently incorporated into studies focused on the development and optimization of peptide-based vaccines. By serving as a model antigen, it allows for the assessment of immunogenicity, adjuvant compatibility, and delivery strategies in preclinical systems. The peptide's ability to elicit specific immune responses in experimental settings supports its use in screening protocols for vaccine candidates targeting angiogenesis-related pathways. This approach aids in the identification of sequence motifs that enhance immunostimulatory potential and guide rational vaccine design.
Angiogenesis Pathway Investigation: The synthetic peptide is instrumental in research targeting angiogenesis, particularly through its relevance to VEGFR2-mediated signaling. Elpamotide enables researchers to probe the functional consequences of disrupting or modulating VEGFR2 activity at the peptide level. In vitro assays leveraging this compound provide insights into endothelial cell behavior, receptor-ligand interactions, and downstream signaling cascades. Such studies contribute to a deeper understanding of the molecular mechanisms governing new blood vessel formation and the regulatory checkpoints involved.
Peptide-Protein Interaction Studies: Elpamotide is a preferred tool for elucidating the biophysical and biochemical interactions between peptides and target proteins. Its application in binding assays, surface plasmon resonance, and structural analyses supports the characterization of affinity and specificity parameters. These investigations inform the rational design of peptide analogs, inhibitors, or mimetics with enhanced functional properties. The peptide's defined structure and target engagement profile make it particularly suitable for mechanistic studies of protein recognition and signal modulation.
Analytical Method Development: In the context of method validation and assay development, Elpamotide serves as a reliable peptide standard. Its stability and sequence definition enable its use in quality control procedures, chromatographic method optimization, and mass spectrometric calibration. Researchers rely on this compound to benchmark assay sensitivity, establish detection limits, and validate peptide quantification protocols. These applications are essential for ensuring the reproducibility and accuracy of analytical workflows in peptide research and development laboratories.
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