MMP Colorimetric Substrate I

An exceptional MMP-2 (gelatinase A) and MMP-9 (gelatinase B) substrate this peptide is used for the continuous spectrophotometric assay of MMP-2 and MMP-9 in combination with a color-developing thiol-reactive agent, 4,4’-dithiodipyridine or Ellman’s Reagent (as indicators). This thiol peptide-enzyme reaction has a Km of 0.004 M and a kcat of 103 s-1. Using this substrate, collagenase can be detected at concentrations as low as 2 ng/mL. HPLC and tandem mass spectrometry are also used to analyze MMP-2 and MMP-9 in conjunction with this peptide substrate.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: X21175

Custom Peptide Synthesis

Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.W/Mr.

655.9

Sequence

One Letter Code: Ac-PLG-SCH[CH2CH(CH3)2]-CO-LG-OC2H5
Three Letter Code: Ac-Pro-Leu-Gly-SCH[CH2CH(CH3)2]-CO-Leu-Gly-OC2H5

References

1. Weingarten, H. and J. Feder, Anal. Biochem. 147, 437 (1985);
2. Weingarten, H. et al. Biochem. 24, 6730 (1985).

1. Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L

2. Zeta-potential-changing nanoparticles conjugated with cell-penetrating peptides for enhanced transfection efficiency

3. A possible role of tachykinin-related peptide on an immune system activity of mealworm beetle, Tenebrio molitor L

4. Investigating Potential Interactions Between Neurohypophyseal Peptides, their Drug Analogs, and Coagulation Factor VIII

5. Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors

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