Norleual is an angiotensin (Ang) IV analog, and acts as highly potent HGF/c-MET inhibitor (IC50 = 3 pM) that inhibits HGF-induced MDCK cell proliferation and invasion in vitro. It also is AT4 receptor antagonist, disrupts LTP stabilization. It shows antiangiogenic activity.
CAT No: R1054
CAS No:334994-34-2
Synonyms/Alias:Norleual;334994-34-2;L-Phenylalanine,L-norleucyl-L-tyrosyl-L-leucyl-y(CH2-NH)-L-histidyl-L-prolyl-;(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-aminohexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid;AKOS025142100;DA-56260;PD080030;G91230;
AngIV analogs such as norleual may also mimic the conformation of the hinge region of HGF. In norleual, the reduced peptide bond increases the rotatability around the 3-4-position, making the molecule more flexible. This may permit norleual to emulate hinge conformations in HGF that are normally induced by tertiary structure (kringles) to facilitate its interaction with the c-Met.
The Angiotensin IV Analog Nle-Tyr-Leu-ψ-(CH2-NH2)3-4-His-Pro-Phe (Norleual) Can Act as a Hepatocyte Growth Factor/c-Met Inhibitor
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