O-Methyl-D-tyrosine is a D-configuration, non-proteinogenic tyrosine derivative in which the phenolic hydroxyl side chain is methylated, converting the native phenol into a methoxy substituent on the aromatic ring. The molecule retains the amino and carboxyl functional groups characteristic of amino acids, while the O-methyl ether reduces phenolic acidity and changes hydrogen-bonding and aromatic electronic properties compared with unmodified tyrosine. As a chemically defined labeled or analog building block, it is used in peptide and structure-activity studies to probe how side-chain O-alkylation affects conformation, receptor or binding-site interactions, and analytical behavior in amino acid and peptide profiling workflows.
CAT No: CP02134
CAS No:39878-65-4
Synonyms/Alias:O-Methyl-D-tyrosine;39878-65-4;4-Methoxy-D-Phenylalanine;(R)-2-Amino-3-(4-methoxyphenyl)propanoic acid;D-Tyrosine, O-methyl-;H-D-Tyr(Me)-OH;(2R)-2-amino-3-(4-methoxyphenyl)propanoic acid;D-4-methoxyphenylalanine;(R)-2-amino-3-(4-methoxyphenyl)propionic acid;Q4LA7968UD;UNII-Q4LA7968UD;(2R)-2-azaniumyl-3-(4-methoxyphenyl)propanoate;D-4-Methoxyphe;H-4-Methoxy-D-Phe-OH;D-Tyrosine, O-methyl-; O-Methyl-D-tyrosine; (2R)-2-Amino-3-(4-methoxyphenyl)propanoic acid; (R)-2-Amino-3-(4-methoxyphenyl)propionic acid; D-4-Methoxyphenylalanine; D-O-Methyltyrosine;MFCD00190961;SCHEMBL597743;CHEBI:192378;GEYBMYRBIABFTA-SECBINFHSA-N;DTXSID801315511;AKOS015851868;132574-59-5;AC-25338;AS-19805;O-Methyl-D-tyrosine, >=99.0% (NT);HY-141526;CS-0179569;M2332;EN300-4226974;
2. The spatiotemporal control of signalling and trafficking of the GLP-1R
4. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
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