O-Methyl-D-tyrosine is a D-configuration, non-proteinogenic tyrosine derivative in which the phenolic hydroxyl side chain is methylated, converting the native phenol into a methoxy substituent on the aromatic ring. The molecule retains the amino and carboxyl functional groups characteristic of amino acids, while the O-methyl ether reduces phenolic acidity and changes hydrogen-bonding and aromatic electronic properties compared with unmodified tyrosine. As a chemically defined labeled or analog building block, it is used in peptide and structure-activity studies to probe how side-chain O-alkylation affects conformation, receptor or binding-site interactions, and analytical behavior in amino acid and peptide profiling workflows.
CAT No: CP02134
CAS No:39878-65-4
Synonyms/Alias:O-Methyl-D-tyrosine;39878-65-4;4-Methoxy-D-Phenylalanine;(R)-2-Amino-3-(4-methoxyphenyl)propanoic acid;D-Tyrosine, O-methyl-;H-D-Tyr(Me)-OH;(2R)-2-amino-3-(4-methoxyphenyl)propanoic acid;D-4-methoxyphenylalanine;(R)-2-amino-3-(4-methoxyphenyl)propionic acid;Q4LA7968UD;UNII-Q4LA7968UD;(2R)-2-azaniumyl-3-(4-methoxyphenyl)propanoate;D-4-Methoxyphe;H-4-Methoxy-D-Phe-OH;D-Tyrosine, O-methyl-; O-Methyl-D-tyrosine; (2R)-2-Amino-3-(4-methoxyphenyl)propanoic acid; (R)-2-Amino-3-(4-methoxyphenyl)propionic acid; D-4-Methoxyphenylalanine; D-O-Methyltyrosine;MFCD00190961;SCHEMBL597743;CHEBI:192378;GEYBMYRBIABFTA-SECBINFHSA-N;DTXSID801315511;AKOS015851868;132574-59-5;AC-25338;AS-19805;O-Methyl-D-tyrosine, >=99.0% (NT);HY-141526;CS-0179569;M2332;EN300-4226974;
1. Implications of ligand-receptor binding kinetics on GLP-1R signalling
2. Cationic cell-penetrating peptides are potent furin inhibitors
3. Emu oil in combination with other active ingredients for treating skin imperfections
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.