Trt-Cys(Trt)-OH is a protected cysteine derivative in which the amino acid framework is converted to a carboxylic acid (-CO2H) and the thiol-bearing cysteine side chain is protected as a trityl (Trt) thioether, giving a Trt-substituted Cys(Trt) motif. The molecule contains the amino (-NH-) and carboxyl (-CO2H) functional groups while bearing trityl protecting groups on the sulfur functionality, with the trityl groups providing steric shielding and chemoselective control during peptide-coupling steps. As a protected amino acid building block, it is used in peptide synthesis workflows to introduce cysteine residues with thiol protection intact for subsequent deprotection and downstream derivatization or conjugation strategies.
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