Z-N-α-methyl-L-Leucine is a protected, non-natural amino acid derivative featuring the leucine backbone with an α-methyl substitution, where the amino group is protected as a benzyloxycarbonyl (Z, Cbz) carbamate and the side chain retains the isobutyl functionality characteristic of leucine. The molecule contains both a carboxylic acid (as the free acid) and the carbamate-protected α-amino group, with stereochemistry indicated as L at the α-carbon relative to the leucine framework and an additional α-methyl substituent that increases steric bulk around the backbone. In peptide synthesis workflows, the Z-protected amino functionality and α-methyl substitution support incorporation of this sterically constrained residue into peptide analogues for structure-activity studies, conformational probing, and chemical biology applications where backbone modification is used to modulate peptide properties.
CAT No: CP01335
CAS No:33099-08-0
Synonyms/Alias:33099-08-0;N-Cbz-N-methyl-L-leucine;Cbz-N-methyl-L-leucine;Z-N-Me-Leu-OH;Z-N-methyl-L-leucine;ST51037722;AmbotzZAA1015;Cbz-N-Me-Leu-OH;Z-N-a-methyl-L-Leucine;Cbz-N-Methyl-L-Leu-OH;N-Methyl-N-Cbz-L-leucine;96925_ALDRICH;SCHEMBL2300007;96925_FLUKA;CTK4G9958;MolPort-003-939-976;TVXSGOBGRXNJLM-ZDUSSCGKSA-N;ZINC2391032;ANW-63420;SBB064567;AKOS015890053;VA50549;AJ-35708;AK-81334;TC-152165
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