N-Fmoc-3-(4-Thienyl)-L-alanine is a thienyl-containing amino acid analog useful for tuning aromatic interactions in peptides. Its heteroaromatic ring supports π–π stacking and potential metal coordination. Researchers incorporate it to probe effects of noncanonical aromatics on folding and binding. The reagent aids design of spectroscopically distinctive or electronically modulated peptide scaffolds.
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