(Nle6)-Sarafotoxin C is a sarafotoxin analog with a norleucine substitution at position 6 that modulates hydrophobic core interactions. The variant retains the typical disulfide-stabilized scaffold of endothelin-like peptides. Its properties enable targeted investigation of endothelin receptor binding and signaling. Researchers employ it to evaluate structure-activity relationships in vasoregulatory toxins.
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